Many efficient frmacos against the cancer exert its action on the cells that if find in the cellular cycle, being called frmacos cycle-cellular specific (CCS). As a group of agents, called frmacos cycle-cellular not specific (CCNS), has the capacity of exterminar the tumorais cells independently to be crossing the cycle or to be in rest in the Go compartment (Graebin and Lima, 2006). Although so far to have postulate that the activity of anti-cancergenos frmacos can only be classified in agents cycle-cellular specific (CCS) or not specific cellular cycle (CCNS), it was observed more recently than, amongst this last, factor most important, for the antitumoral activity and potentiality for its use in the treatment of the different neoplasias, it is that the studied antitumorais most used and are agents who generally act as eletrfilos on nucleoflicas macro-molecules, particularly the DNA (Hahn and Weinberg, 2002). However, although to admit itself that these agents are not cycle-cellular specific, already it was observed that the cells are more sensible to the alquilao in phases G and S of the cellular cycle, presenting blockade in G2. These antitumorais agents comprovadamente form linkings crossed with ribbons or filaments of DNA, being able themselves to observe, the different types of crossed linkings that can occur (Hahn and Weinberg, 2002). All these linkings produce injuries in the DNA, being that provoked for the crossed linkings interfilamentares is most cytotoxic, therefore the alquilao of an only filament of DNA can easily until being repaired, but the linkings cruzades interfilamentares, with the produced ones for bifunctional alquilantes agents, demand more complex mechanisms of repairing, being able until inhibiting its response (Almeida et al., 2005). It has diverse classrooms of antineoplsicos agents who have this type of action mechanism: nitrogenadas mustards, nitrossurias, triazeno, alquilsulfonatos, complexes of platinum coordination and others. It fits to stand out, first, that these alquilantes agents are strong eletroflicos reagents, forming linkings crossed covalentes for reaction of alquilao with nucleoflicos centers of the DNA, mainly the purnicas and pirimidnicas bases (Rajski and Williams, 1998).
Recent Posts
Archives
- March 2022
- February 2022
- January 2022
- December 2021
- June 2021
- April 2021
- March 2021
- February 2021
- January 2021
- July 2020
- June 2020
- May 2020
- April 2020
- March 2020
- February 2020
- December 2019
- November 2019
- October 2019
- August 2019
- May 2019
- April 2019
- February 2019
- January 2019
- December 2018
- November 2018
- June 2018
- April 2018
- March 2018
- January 2018
- September 2017
- August 2017
- July 2017
- June 2017
- May 2017
- April 2017
- March 2017
- February 2017
- January 2017
- December 2016
- November 2016
- October 2016
- September 2016
- August 2016
- July 2016
- June 2016
- May 2016
- April 2016
- March 2016
- February 2016
- January 2016
- December 2015
- November 2015
- June 2015
- June 2014
- May 2014
- April 2014
- March 2014
- February 2014
- January 2014
- December 2013
- November 2013
- October 2013
- September 2013
- August 2013
- July 2013
- June 2013
- May 2013
- April 2013
- March 2013
- February 2013
- January 2013
- December 2012
- November 2012
- October 2012
- September 2012
- July 2012
- June 2012
- May 2012
- April 2012
- March 2012
- February 2012
- January 2012
- December 2011
- November 2011
- October 2011